This program explores the life cycle of animals and plants. It encompasses gamete formation, embryonic development, maturation, growth, reproduction, regeneration, aging, and death. It focuses on processes like cell proliferation, differentiation, and spatial organization, crucial especially in early developmental stages but relevant throughout life. Drawing from cellular and molecular biology, it delves into embryology, morphology, genetics, examining gene expression and its regulation. It formulates an overall picture of cell interactions within organisms.
Application for the programme starting in the winter semester by:
30. 4. 2025
Detailed information about the study programme
Offer of dissertation topics:
- piRNA and genome defense in gastropods
- Advancing Breast Morphogenesis Modeling through Novel Human Mammary Organoids
- Analysis of metabolic dependencies in acute myeloid leukemia
- Construction of new sensors for activity of chemotactic GPCRs.
- Crosstalk between Dishevelled and eukaryotic cytoskeleton
- Development of methods to study 5’ RNA termini structure and sequence
- Evolutionary adaptations of animal RNA silencing mechanisms
- Expanding the single-molecule toolbox to visualize ciliary compartmentalization in C. elegans neurons
- FBXO38, a Component of the SCF Ubiquitin Ligase Complex, and its Role in Immune Regulation
- CHANGES IN CONTROL AND ASSEMBLY OF CHROMOSOME SEGREGATION APPARATUS IN CELLS DURING EARLY DEVELOPMENT
- Characterization of Mouse Breast Milk and Maternal-Fetal Microchimerism Established During Lactation
- Initiation phase is a crucial step determining regeneration efficiency
- Investigating the Role of CRL1 in Development and Cancer
- Impact of mesenchymal cells on the intestinal epithelium homeostasis, regeneration and tumorigenesis
- Mechanisms of lysosomal protein degradation
- Metabolic reprogramming of cancer cells upon changes in style of migration
- Molecular Regulation of Lactation: Investigating DNA Replication, Transcription, and Damage Repair
- New mechanisms regulating function of the tumor suppressor p53 in human cells
- Nuclear actin-binding proteins in the regulation of cellular differentiation
- Properties and the role of non-canonical RNA caps in cells
- Redox mechanisms of insulin secretion
- Reduction of Trp content in minimal cell model using genome engineering and de novo genome synthesis
- Regulation of growth and metabolism by the mTOR pathway
- Regulation of intracellular transport by interactions between intermediate filaments and microtubules
- Regulation of mitochondrial transport by the interplay between metabolites and adaptor proteins
- Regulation of tau envelope by tau post-translational modifications
- Role of normal and mutant huntingtin in neural cells.
- Structural studies of histone chaperones
- Subcellular Processing of Exosomes in the Context of Alzheimer´s Disease
- Targeting isolated biliary atresia: early diagnosis and trustworthy disease model development.
- The impact of biological sex on mitochondrial metabolism in cardiomyocytes
- The impact of female age on oocyte quality and the ability of oocytes to repair ssDNA breaks
- The impact of sex chromosomes on cardiometabolic adaptations during obesity
- The role of phosphoinositides in spatiotemporal regulation of nuclear processes
- Understanding the specificity of intramembrane proteases using biophysical principles and artificial intelligence
- Unravelling the effect of cellular metabolites on the cytoskeletal dynamics
Profile of the graduate
Ph.D. graduate has extensive knowledge of cell and developmental biology, ranging from basic principles of molecular and cell biology and practical methods, to applications in cellular and developmental pathology. After the completion of the doctoral thesis, the graduate is well versed in specialized experimental approaches, can work with scientific literature and knows basic principles of scientific work, adopting ethical guidelines and observing rules of conduct in scientific publishing. The graduate is capable of independently solving both theoretical and practical problems encountered during research work. The graduate is fluent in scientific English and is capable of formulating her/his opinions so that they can be presented to the international scientific community. The program entitles the graduates to find placement in universities or academic institutions to work on research projects, in medical institutions as members of research teams or in clinical laboratories, in applied research sector as well in biotech companies.
Application submission
The application is submitted electronically through the Charles University study information system. The completed application must be submitted electronically in the study information system no later than on 30. 4. 2025 for study programmes starting in the winter semester (October) and no later than on 15. 12. 2025 for study programmes starting in the summer semester (April).
The admission fee is 100 EUR and it is paid for each submitted application.
Entrance exam
The regular date of entrance exam for all doctoral programmes starting in the winter semester (October) is 9. - 20. 6. 2025, an alternative date is 23. - 27. 6. 2025.
The regular date of entrance exam for all doctoral programmes starting in the summer semester (April) is 4. - 5. 2. 2026, an alternative date is 11. - 12. 2. 2026.
The request for an alternative day is submitted and approved via the electronic information system.
The form of the entrance exam is an oral interview, which mainly concerns the issues of the planned dissertation and the candidate's knowledge within the field of expertise of the given study programme.
Find more information in:
- Conditions of the admission procedure for doctoral study programmes at the Faculty of Science, Charles University, for study programmes starting in the winter semester (October)
or - Conditions of the admission procedure for doctoral study programmes at the Faculty of Science, Charles University, for study programmes starting in the summer semester (April).
Important links
Detailed description of the study program on the website of the Department of Cell Biology
Applicants with specific needs
If you have a physical handicap, you can apply for a modification of the entrance exam. For more information read the Conditions of the admission procedure for doctoral study programmes.
Departments involved in this programme
Guarantor of the study programme
prof. RNDr. Jan Černý, Ph.D.
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Do you have a question?
Complete information about the admission procedure can be found on the website for applicants. For questions, please contact the admissions contact persons.